2',3'-Dideoxycytidine

《英文msh词典》2',3'-Dideoxycytidine
[同义词] 2',3'-Dideoxycytidine
[主题词] Zalcitabine
[药动学] Reverse Transcriptase Inhibitors
[中文释义] 2',3'-双去氧胞苷
[英文释义] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations,acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.