Gene,BRCA2

《英文msh词典》Gene,BRCA2
[入口词] Gene,BRCA2
[主题词] Genes,BRCA2
[英文释义] A tumor suppressor gene (GENES,SUPPRESSOR,TUMOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large,nuclear protein that is an essential component of DNA repair pathways,suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)