Antineoplastics,Alkylating
《英文msh词典》Antineoplastics,Alkylating
[入口词] Antineoplastics,Alkylating
[主题词] Antineoplastic Agents,Alkylating
[英文释义] A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups,that after metabolism,can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA,Drug Evaluations Annual,1994,p2026)
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